Cardiac Protein Lab

Welcome to the Cardiac Protein Lab. This lab, led by Dr. Todd Gillis, is focused on the vertebrate heart and the mechanisms that regulate it’s function and ability to remodel in response to a physiological stressor. Ongoing projects include:

  • Examining cardiac remodeling in zebrafish and trout in response to thermal acclimation
  • Characterizing the role of the troponin complex in regulating the function of striated muscle
  • Examining the function of the hagfish heart during prolonged anoxia exposure
  • .Examining the change in diaphragm function during the onset of heart failure
  • Characterizing how bitumen exposure of sockeye salmon early life stages influences cardiac development and aerobic fitness.

We use a number of approaches in these studies that integrate functional experiments with molecular and proteomic tools to examine gene and protein expression/phosphorylation. This integration provides insight into the cellular mechanisms that underpin identified functional changes.

There are currently positions in the lab for MSc and PhD students. Please explore our current work via the “Research page” and then contact Dr. Gillis via email regarding your interests.

Gillis Lab News

  • March 2017. Hagfish Article in National Geographic mentions studies by Calli Freedman and Todd Gillis
  • February 2017. Calli Freedman is awarded an Ontario Graduate Scholarship. Congratulations Calli!
  • November 2016. Invited Review published in the Journal of Experimental Biology entitled: Temperature-induced cardiac remodeling in fish. Authors are Drs. Adam Keen (Oxford), Jordan Klaiman (U Washington), Holly Shiels (Manchester) and Todd Gillis.

Research in the Gillis Lab