Cardiac Protein Lab

Publications

Adam. N. Keen, Jordan M. Klaiman, Holly A. Shiels and Todd E. Gillis, Temperature-induced cardiac remodeling in fish. Journal of Experimental Biology (2017) 220, 147-160 doi:10.1242/jeb.128496

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Sarah L. Alderman, Feng Lin, Anthony P. Farrell, Christopher J. Kennedy and Todd E. Gillis. Effects of diluted bitumen exposure on juvenile sockeye salmon: from cells to performance. Environmental Toxicology and Chemistry, 2016

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Elizabeth J. Sears, and Todd E. Gillis. A functional comparison of cardiac troponin C from representatives of three vertebrate taxa: Linking phylogeny and protein function. Comparative Biochemistry and Physiology. B

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Todd E. Gillis, Jordan M. Klaiman, Andrew Foster, Mathew J. Platt, Jason S. Huber, Melissa Y. Corso, and Jeremy A. Simpson.  Dissecting the role of the myofilament in diaphragm dysfunction during the development of heart failure in mice American Journal of Physiology, Heart and Circulatory Physiology, 310: H572–H586, 2016.
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Characterizing the metabolic capacity of the anoxic hagfish heart
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Jordan M. Klaiman, W. Glen Pyle and Todd E. Gillis, Cold acclimation increases cardiac myofilament function and ventricular pressure generation in trout, The Journal of Experimental Biology (2014) 217, 4132-4140

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Pinto, N., Yang, F. C., Negishi, A., Rheinstädter, M. C., Gillis, T. E., & Fudge, D. S. (2014). Self-assembly enhances the strength of fibers made from vimentin intermediate filament proteins. Biomacromolecules15(2), 574-581.

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Johnson, A. C., Turko, A. J., Klaiman, J. M., Johnston, E. F., & Gillis, T. E. (2014). Cold acclimation alters the connective tissue content of the zebrafish (Danio rerio) heart. The Journal of experimental biology217(11), 1868-1875.

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Johnston, E. F., Alderman, S. L., & Gillis, T. E. (2013). Chronic Hypoxia Exposure of Trout Embryos Alters Swimming Performance and Cardiac Gene Expression in Larvae. Physiological and Biochemical Zoology86(5), 567-575.

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Smith, G. S., Samborska, B., Hawley, S. P., Klaiman, J. M., Gillis, T. E., Jones, N., … & Harauz, G. (2013). Nucleus‐localized 21.5‐kDa myelin basic protein promotes oligodendrocyte proliferation and enhances neurite outgrowth in coculture, unlike the plasma membrane‐associated 18.5‐kDa isoform. Journal of neuroscience research91(3), 349-362.

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Alderman, S. L., Klaiman, J. M., Deck, C. A., & Gillis, T. E. (2012). Effect of cold acclimation on troponin I isoform expression in striated muscle of rainbow trout. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology303(2), R168-R176.

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Gillis, T. E. (2012). Evolution of the Regulatory Control of the Vertebrate Heart: The Role of the Contractile Proteins. In Ontogeny and Phylogeny of the Vertebrate Heart (pp. 125-145). Springer New York.

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Negishi, A., Armstrong, C. L., Kreplak, L., Rheinstadter, M. C., Lim, L. T., Gillis, T. E., & Fudge, D. S. (2012). The production of fibers and films from solubilized hagfish slime thread proteins. Biomacromolecules13(11), 3475-3482.

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Gillis, T. E., & Klaiman, J. M. (2011). The influence of PKA treatment on the Ca2+ activation of force generation by trout cardiac muscle. The Journal of experimental biology214(12), 1989-1996.

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Kirkpatrick, K. P., Robertson, A. S., Klaiman, J. M., & Gillis, T. E. (2011). The influence of trout cardiac troponin I and PKA phosphorylation on the Ca2+ affinity of the cardiac troponin complex. The Journal of experimental biology,214(12), 1981-1988.

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Miller, S. C., Gillis, T. E., & Wright, P. A. (2011). The ontogeny of regulatory control of the rainbow trout (Oncorhynchus mykiss) heart and how this is influenced by chronic hypoxia exposure. The Journal of experimental biology,214(12), 2065-2072.

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Gillis, T.E. (2011). Cardiac Excitation–Contraction Coupling: Calcium and the Contractile Element. Encyclopedia of Fish Physiology: From Genome to Environment 2, 1054-1059

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Klaiman, J. M., Fenna, A. J., Shiels, H. A., Macri, J., & Gillis, T. E. (2011). Cardiac remodeling in fish: strategies to maintain heart function during temperature change. PloS one6(9), e24464.

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Shaffer, J. F., & Gillis, T. E. (2010). Evolution of the regulatory control of vertebrate striated muscle: the roles of troponin I and myosin binding protein-C.Physiological genomics42(3), 406-419.

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Miller, S. C., Reeb, S. E., Wright, P. A., & Gillis, T. E. (2008). Oxygen concentration in the water boundary layer next to rainbow trout (Oncorhynchus mykiss) embryos is influenced by hypoxia exposure time, metabolic rate, and water flow. Canadian Journal of Fisheries and Aquatic Sciences65(10), 2170-2177.

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Liang, B., Chung, F., Qu, Y., Pavlov, D., Gillis, T. E., Tikunova, S. B., … & Tibbits, G. F. (2008). Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility. Physiological genomics33(2), 257-266.

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Gillis, T. E., Marshall, C. R., & Tibbits, G. F. (2007). Functional and evolutionary relationships of troponin C. Physiological genomics32(1), 16-27.

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Gillis, T. E., Martyn, D. A., Rivera, A. J., & Regnier, M. (2007). Investigation of thin filament near-neighbour regulatory unit interactions during force development in skinned cardiac and skeleta muscle. The Journal of physiology,580(2), 561-576.

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Kreutziger, K. L., Gillis, T. E., Davis, J. P., Tikunova, S. B., & Regnier, M. (2007). Influence of enhanced troponin C Ca2+-binding affinity on cooperative thin filament activation in rabbit skeletal muscle. The Journal of physiology583(1), 337-350.

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Moreno-Gonzalez, A., Gillis, T. E., Rivera, A. J., Chase, P. B., Martyn, D. A., & Regnier, M. (2007). Thin-filament regulation of force redevelopment kinetics in rabbit skeletal muscle fibres. The Journal of physiology579(2), 313-326.

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Gillis, T. E., Liang, B., Chung, F., & Tibbits, G. F. (2005). Increasing mammalian cardiomyocyte contractility with residues identified in trout troponin C.Physiological genomics22(1), 1-7.

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Blumenschein, T. M., Gillis, T. E., Tibbits, G. F., & Sykes, B. D. (2004). Effect of temperature on the structure of trout troponin C. Biochemistry43(17), 4955-4963.

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Gillis, T. E., Blumenschein, T. M., Sykes, B. D., & Tibbits, G. F. (2003). Effect of temperature and the F27W mutation on the Ca2+ activated structural transition of trout cardiac troponin C. Biochemistry42(21), 6418-6426.

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Gillis, T. E., Moyes, C. D., & Tibbits, G. F. (2003). Sequence mutations in teleost cardiac troponin C that are permissive of high Ca2+ affinity of site II. American Journal of Physiology-Cell Physiology284(5), C1176-C1184.

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Gillis, T. E., & Tibbits, G. F. (2002). Beating the cold: the functional evolution of troponin C in teleost fish. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology132(4), 763-772.

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Gillis, T. E., Marshall, C. R., Xue, X. H., Borgford, T. J., & Tibbits, G. F. (2000). Ca2+ binding to cardiac troponin C: effects of temperature and pH on mammalian and salmonid isoforms. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology279(5), R1707-R1715.

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Gillis, T. E., & Ballantyne, J. S. (1999). Influences of subzero thermal acclimation on mitochondrial membrane composition of temperate zone marine bivalve mollusks. Lipids34(1), 59-66.

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Gillis, T. E., & Ballantyne, J. S. (1999). Mitochondrial membrane composition of two arctic marine bivalve mollusks, Serripes groenlandicus and Mya truncata. Lipids34(1), 53-57.

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Stuart, J. A., Gillis, T. E., & Ballantyne, J. S. (1998). Compositional correlates of metabolic depression in the mitochondrial membranes of estivating snails.American Journal of Physiology-Regulatory, Integrative and Comparative Physiology275(6), R1977-R1982.

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Stuart, J. A., Gillis, T. E., & Ballantyne, J. S. (1998). Remodeling of phospholipid fatty acids in mitochondrial membranes of estivating snails. Lipids33(8), 787-793.

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Gillis, T. E., & Ballantyne, J. S. (1996). The effects of starvation on plasma free amino acid and glucose concentrations in lake sturgeon. Journal of fish biology,49(6), 1306-1316.

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LeBlanc, P. J., Gillis, T. E., Gerrits, M. F., & Ballantyne, J. S. (1995). Metabolic organization of liver and somatic muscle of landlocked sea lamprey, Petromyzon marinus, during the spawning migration. Canadian journal of zoology73(5), 916-923.