Publications
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Born in complexity: How the early life environment shapes zebrafish larvae phenotype
Boudeau, J.A., and Alderman, S.L. (2025) Comparative Biochemistry and Physiology – Part A. 310:111930. Abstract: The biotic and abiotic environments are potent drivers of individual plasticity. Zebrafish, a popular research model around the world, has been extensively used for understanding the proximate cause and mechanisms of phenotypic plasticity to environmental enrichment. Despite…
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Temperature matters: acute and latent toxicity of diluted bitumen to developing salmon is potentiated by a modest increase in water temperature.
Calik, D.M., Lin, F., Edgar, M., Kennedy, C.J., Johnston, E.F., Farrell, A.P., Gillis, T.E.*, Alderman, S.L.* (2025). Aquatic Toxicology 283:107347. *co-senior authors Abstract: Heavy crude oil, like bitumen, is used globally for plastics, petrochemicals and road surfacing. Canada’s oil sands are the world’s third largest crude oil reserve, and diluted…
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Encyclopedia of Fish Physiology 2nd Edition: From Mechanism to Application
Alderman, S.L., and Gillis, T.E. (2024) Academic Press. About: Encyclopedia of Fish Physiology, Second Edition is a comprehensive, introductory-level reference work that aims to unite readers in the wonders of this discipline. Chapters highlight where physiological systems and processes are conserved across vertebrate groups, which supports the use of fish as a vertebrate model…
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Development of the hypothalamus-pituitary-interrenal axis
Alderman, S.L. (2024) Encyclopedia of Fish Physiology 2nd edition, Volume 1, pp 233-241. Abstract: The development and maturation of the hypothalamus-pituitary-interrenal axis (HPI axis) determines when a fish will be able to respond to environmental stressors through active and integrative homeostatic regulation. Studies from zebrafish provide a comprehensive overview of HPI axis development.…
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11β-Hydroxysteroid dehydrogenase type 2 may mediate thestress-specific effects of cortisol on brain cell proliferation in adultzebrafish (Danio rerio)
Flatt, E.E., and Alderman, S.L. (2024) Journal of Experimental Biology. 227:jeb248020. Abstract: Stress-induced increases in cortisol can stimulate or inhibit brain cell proliferation, but the mechanisms behind these opposing effects are unknown. We tested the hypothesis that 11β-hydroxysteroid dehydrogenase type 2 (Hsd11b2), a glucocorticoid-inactivating enzyme expressed in neurogenic regions of the adult…
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Age matters: Comparing life-stage responses to diluted bitumen exposure in coho salmon (Oncorhynchus kisutch)
Perugini, G., Edgar, M., Lin, F., Kennedy, C.J., Farrell, A.P., Gillis, T.E., Alderman S.L. (2022) Aquatic Toxicology 253:106350 Abstract: Millions of liters of diluted bitumen (dilbit), a crude oil product from Canada’s oil sands region, is transported through critical Pacific salmon habitat each day. While the toxicity of the water-soluble fraction of dilbit…
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Applied aspects of fish endocrinology
Bernier, N.J., and Alderman S.L. (2022) Chapter 6, in: Conservation Physiology of the Anthropocene-A Systems Approach. Fish Physiology 39A:253-320. Abstract: Endocrine systems are regulators of physiological responses to environmental conditions, acting as key transmitters of external and internal cues, and can therefore provide valuable insights to help address pressing issues in fish conservation biology. In…
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Diluted bitumen affects multiple physiological systems in sockeye salmon (Oncorhynchus nerka) embryo to juvenile life stages
Lin, F., Alderman, S.L., Gillis, T.E., Kennedy, C.J. (2022) Environmental Toxicology and Chemistry 41:1937-1949 Abstract: An understanding of the risks associated with diluted bitumen (dilbit) transport through Pacific salmon habitat necessitates the identi cation and quanti cation of hazards posed to early life stages. Sockeye from the embryo to juvenile stage (8…
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Lake charr (Salvelinus namaycush) clotting response may act as a plasma biomarker of sea lamprey (Petromyzon marinus) parasitism: implications for management and wound assessment
Bullingham, O.M.N., Firkhus, T.J., Goetz, F.W., Murphy, C.A., Alderman, S.L. (2022) Journal of Great Lakes Research 48:207-218 Abstract: Sea lampreys (Petromyzon marinus) have decimated the Great Lakes fisheries over the past century, and their control is central to protecting native fish populations. Wounding data collected from host fish, including classifying wounds as…
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Cold-acclimation induces life stage-specific responses in the cardiac proteome of Western painted turtles (Chrysemys picta bellii): implications for anoxia tolerance
Alderman, S.L., Riggs, C.L., Bullingham, O.M.N., Gillis, T.E., Warren, D.E. (2021) Journal of Experimental Biology 224:jeb242387 Abstract: Western painted turtles (Chrysemys picta bellii) are the most anoxia-tolerant tetrapod. Survival time improves at low temperature and during ontogeny, such that adults acclimated to 3°C survive far longer without oxygen than either warm-acclimated…
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Growing up gator: a proteomic perspective on cardiac maturation in an oviparous reptile, the American alligator (Alligator mississippiensis)
Alderman, S.L., Crossley, D.A., Elsey, R.M., Gillis, T.E. (2020) Journal of Comparative Physiology B 190:243-252 Abstract: We recently described lasting changes in the cardiac proteome of American alligators (Alligator mississippiensis) reared under hypoxic conditions, that resemble what embryos encounter in natural nests. While these changes were consistent with functional differences in…
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Effects of diluted bitumen exposure on Atlantic salmon smolts: Molecular and metabolic responses in relation to swimming performance
Avey, S.R., Kennedy, C.J., Farrell, A.P., Gillis, T.E., Alderman, S.L. (2020) Aquatic Toxicology 221:1054423 Abstract: Canada’s oil sands industry continues to expand and the volume of diluted bitumen (dilbit) transported across North America is increasing, adding to spill risk and environmental contamination. Dilbit exposure is known to cause adverse effects in…
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Effects of diluted bitumen exposure and recovery on seawater acclimation response of Atlantic salmon smolts
Alderman, S.L., Dilkumar, C.M., Avey, S.R., Farrell, A.P., Kennedy, C.J., Gillis, T.E. (2020) Aquatic Toxicology 221:105419 Abstract: Petrogenic chemicals are common and widespread contaminants in the aquatic environment. In Canada, increased extraction of bitumen from the oil sands and transport of the major crude oil export product, diluted bitumen (dilbit), amplifies…
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Hypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics
Alderman, S.L., Crossley, D.A.II., Elsey, R.M., Gillis, T.E. (2019) Scientific Reports 9(1):8592 Abstract: Hypoxic exposure during development can have a profound influence on offspring physiology, including cardiac dysfunction, yet many reptile embryos naturally experience periods of hypoxia in buried nests. American alligators experimentally exposed to developmental hypoxia demonstrate morphological and functional…
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Social stress increases plasma cortisol and reduces forebrain cell proliferation in subordinate male zebrafish (Danio rerio)
Tea, J., Alderman, S.L., and Gilmour, K.M. (2019) Journal of Experimental Biology 2019 222:jeb194894 Abstract: Many animals, including zebrafish (Danio rerio), form social hierarchies through competition for limited resources. Socially subordinate fish may experience chronic stress, leading to prolonged elevation of the glucocorticoid stress hormone cortisol. As elevated cortisol levels can…
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Corticotropin-releasing factor regulates caspase-3 to protect developing zebrafish from stress-induced apoptosis
Alderman, S.L., Leishman, E.M., Fuzzen, M.L.M., Bernier, N.J. (2018) General and Comparative Endocrinology 265:207-213 Abstract: The corticotropin-releasing factor (CRF) system is expressed in the earliest stages of zebra sh development, long before its canonical function in the endocrine stress response is realized, and yet its function during embryogenesis is unknown. We…
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Identification of the actc1c cardiac actin gene in zebrafish
Ojehomon, M., Alderman, S.L., Sandhu, L., Sutcliffe, S., Van Raay, T., Gillis, T.E., Dawson, J.F. (2018) Progress in Biophysics and Molecular Biology 138:32-37 Abstract: Zebrafish is rapidly becoming a key model organism for studying a variety of biological processes from molecules to organisms. Interactions involving actin, a contractile protein and part…
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Developmental and latent effects of diluted bitumen exposure on early lifestages of sockeye salmon (Oncorhynchus nerka),
Alderman, S.L., Lin, F., Gillis, T.E., Farrell, A.P., Kennedy, C.J. (2018) Aquatic Toxicology 202:6–15 Abstract: The early life stages of Pacific salmon are at risk of environmental exposure to diluted bitumen (dilbit) as Canada’s oil sands industry continues to expand. The toxicity and latent effects of dilbit exposure were assessed in…
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Proteomic analysis of sockeye salmon serum as a tool for biomarker discovery and new insight into the sublethal toxicity of diluted bitumen
Alderman, S.L., Dindia, L.A., Kennedy, C.J., Farrell, A.P., Gillis, T.E. (2017) Comparative Biochemistry and Physiology – Part D 22:157-166 Abstract: Pipelines carrying diluted bitumen (dilbit) from Canada’s oil sands traverse North America, including the freshwater habitat of Pacfic salmon, posing a risk of environmental release and aquatic exposure. Swimming performance is…
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Novel insights into cardiac remodelling revealed by proteomic analysis of the trout heart during exercise training
Dindia, L.A., Alderman, S.L., and Gillis. T.E. (2017) Journal of Proteomics 161:38-46
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Data for iTRAQ-based quantification of the cardiac proteome of rainbow trout (Oncorhynchus mykiss) at rest and with exercise training
Dindia, L.A., Alderman, S.L., and Gillis, T.E. (2017) Data in Brief, 13:32–36
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Effects of diluted bitumen exposure on juvenile sockeye salmon: from cells to performance
Alderman, S.L., Lin, F., Farrell, A.P., Kennedy, C.J., Gillis, T.E. (2017) Environmental Toxicology and Chemistry 36:354-360
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Evidence for a plasma-accessible carbonic anhydrase in the lumen of salmon heart that may enhance oxygen delivery to the myocardium
Alderman, S.L., Harter, T.S., Wilson, J.M., Supuran, C.T., Farrell, A.P., Brauner, C.J. (2016) Journal of Experimental Biology 219:719-724 Abstract: Oxygen supply to the heart of most teleosts, including salmonids, relies in part or in whole on oxygen-depleted venous blood. Given that plasma-accessible carbonic anhydrase (CA) in red muscle of rainbow trout…
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11beta-hydroxysteroid dehydrogenase type 2 in the zebrafish brain: a functional role in HPI axis regulation
Alderman, S.L. and Vijayan, M.M. (2012) Journal of Endocrinology 215:1-11 Abstract: The type 2, 11b-hydroxysteroid dehydrogenase (Hsd11b2) converts active glucocorticoids to their inactive derivatives (e.g. cortisol to cortisone). In most vertebrates, Hsd11b2 is essential for conferring aldosterone-specific actions in mineralocorticoid target tissues and for protecting glucocorticoid-sensitive tissues during stress. However, teleosts…